Azatadina

Azatadina (nome comercial: Optimina) é um anti-histamínico de primeira geração e anticolinérgico que foi lançado pela Schering-Plough em 1973.[1][2]

Estrutura química de Azatadina
Azatadina
Aviso médico
Nome IUPAC (sistemática)
11-(1-metilpiperidin-4-ildeno)-6,11-di-hidro-5H-benzo[5,6]ciclohepta[1,2-b]piridina
Identificadores
CAS 3964-81-6
ATC R06AX09
PubChem 19861
DrugBank DB00719
ChemSpider 18709
Informação química
Fórmula molecular C20H22N2 
Massa molar 290.402 g/mol
SMILES n4c3\C(=C1/CCN(C)CC1)c2ccccc2CCc3ccc
Farmacocinética
Biodisponibilidade  ?
Metabolismo  ?
Meia-vida  ?
Excreção  ?
Considerações terapêuticas
Administração  ?
DL50  ?

Foi patenteado em 1967.[3] Tem sido sucedido por outros anti-histamínicos[4] e as aprovações de marketing foram amplamente retiradas.[5][6][7][8][9]

Ver também

Referências
  1. Katelaris, C. (1990). «Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis». Asian Pacific Journal of Allergy and Immunology. 8 (2): 103–107. PMID 1982614
  2. Small, P.; Barrett, D.; Biskin, N. (1990). «Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal provocation». Annals of Allergy. 64 (2 Pt 1): 129–131. PMID 1968324
  3. Azatadine, Villani, F. J.; Caldwell, W. Patente E.U.A. 3 326 924 (1967).
  4. Horak F. Antialergic and Vasoactive Drugs for Allergic Rhinitis. Chapter 4 in Allergy Frontiers:Therapy and Prevention. Volume 5 of Allergy Frontiers. Eds Pawankar R et al Springer Science & Business Media, 2010 ISBN 9784431993629
  5. Drugs.com Drugs.com listing for Azatadine Page accessed July 3, 2015
  6. Federal Register 2005 Food and Drug Administration Docket No.2005N-0058: Hospira, Inc. et al.; Withdrawal of Approval of 76 New Drug Applications and 60 Abbreviated New Drug Applications 70 FR 10651
  7. Federal Register 2007 Food and Drug Administration Docket No. 2004P-0262: Withdrawal of Approval of 128 Suitability Petitions 72 FR 8184
  8. Department of Economic and Social Affairs of the United Nations Secretariat Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals United Nations – New York, 2005
  9. FDA OGD Suitability Tracking Report (Sorted by Drug Name) Page accessed July 3, 2015
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.