Catecol O-Metiltransferase

COMT
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD
Identificadores
Nomes alternativos	COMT
IDs externos	OMIM: 116790 HomoloGene: 30982 GeneCards: COMT
Targeted by Drug
	entacapone, tolcapona, Viroporin 3a[1]
Ontologia genética
Função molecular	• transferase activity; • O-methyltransferase activity; • metal ion binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • magnesium ion binding; • catechol O-methyltransferase activity; • GO:0102674, GO:0102675 methyltransferase activity; • L-dopa O-methyltransferase activity; • orcinol O-methyltransferase activity;
Componente celular	• citoplasma; • integral component of membrane; • corpo celular; • citosol; • postsynaptic membrane; • membrane; • membrana plasmática; • Espinha dendrítica; • axónio; • dendrito; • mitocôndria; • Exossoma; • intracellular membrane-bounded organelle;
Processo biológico	• multicellular organismal reproductive process; • negative regulation of smooth muscle cell proliferation; • GO:1904578 response to organic cyclic compound; • regulation of sensory perception of pain; • estrogen metabolic process; • cellular response to phosphate starvation; • catechol-containing compound metabolic process; • female pregnancy; • negative regulation of dopamine metabolic process; • GO:0007571 developmental process; • aprendizagem; • catecholamine metabolic process; • neurotransmitter catabolic process; • response to lipopolysaccharide; • metilação; • dopamine metabolic process; • response to pain; • memória a curto prazo; • negative regulation of renal sodium excretion; • dopamine catabolic process; • positive regulation of homocysteine metabolic process; • catecholamine catabolic process; • response to estrogen;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ; ; ;
	Mais dados de referência de expressão
Ortólogos
	1312
	n/a
	ENSG00000093010
	n/a
	P21964
	n/a
	NM_000754; NM_001135161; NM_001135162; NM_007310; NM_001362828
	n/a
	NP_000745; NP_001128633; NP_001128634; NP_009294; NP_001349757
	n/a
	Wikidata
Ver/Editar Humano

A Catecol O-Metiltransferase, ou simplesmente COMT, é uma das muitas enzimas que degradam catecolaminas (dopamina, epinefrina e norepinefrina).[3]

Referências

«Drogas que interagem fisicamente com Catechol-O-methyltransferase ver/editar referências no wikidata»
«Human PubMed Reference:»
«Test ID: COMT: Catechol-O-Methyltransferase Genotype». www.mayomedicallaboratories.com. Mayo Clinic: Mayo Medical Laboratories. Consultado em 16 de novembro de 2016. Arquivado do original em 18 de setembro de 2008

Leitura adicional

Trendelenburg U (1991). «The interaction of transport mechanisms and intracellular enzymes in metabolizing systems». Journal of Neural Transmission. Supplementum. 32: 3–18. ISBN 978-3-211-82239-5. PMID 2089098. doi:10.1007/978-3-7091-9113-2_1
Zhu BT (outubro de 2002). «On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis». Histology and Histopathology. 17 (4): 1283–91. PMID 12371153
Oroszi G, Goldman D (dezembro de 2004). «Alcoholism: genes and mechanisms». Pharmacogenomics. 5 (8): 1037–48. PMID 15584875. doi:10.1517/14622416.5.8.1037
Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L (janeiro de 2005). «Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis». Biological Psychiatry. 57 (2): 139–44. PMID 15652872. doi:10.1016/j.biopsych.2004.10.018
Tunbridge EM, Harrison PJ, Weinberger DR (julho de 2006). «Catechol-O-methyltransferase, cognition, and psychosis: Val¹⁵⁸Met and beyond». Biological Psychiatry. 60 (2): 141–51. PMID 16476412. doi:10.1016/j.biopsych.2005.10.024
Craddock N, Owen MJ, O'Donovan MC (maio de 2006). «The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons». Molecular Psychiatry. 11 (5): 446–58. PMID 16505837. doi:10.1038/sj.mp.4001808
Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE (outubro de 2007). «Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning». Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16311–6. PMC 2042203. PMID 17913879. doi:10.1073/pnas.0706111104
Greenberg, Gary (7 de novembro de 2018). «What If the Placebo Effect Isn't a Trick?». New York Times Magazine

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[1] «Drogas que interagem fisicamente com Catechol-O-methyltransferase ver/editar referências no wikidata»

[2] «Human PubMed Reference:»

[3] «Test ID: COMT: Catechol-O-Methyltransferase Genotype». www.mayomedicallaboratories.com. Mayo Clinic: Mayo Medical Laboratories. Consultado em 16 de novembro de 2016. Arquivado do original em 18 de setembro de 2008