Cereblon

Cereblon
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	4M91
Identificadores
Símbolos	CRBN; MRT2; MRT2A
IDs externos	OMIM: 609262 MGI: 1913277 HomoloGene: 9461 GeneCards: CRBN Gene
Número EC	3.4.-
Ontologia do gene
Função molecular	•ATP-dependent peptidase activity; •protein binding;
Componente celular	•nucleus; •nucleolus; •cytoplasm; •membrane; •Cul4A-RING E3 ubiquitin ligase complex;
Processo biológico	•ATP catabolic process; •protein ubiquitination; •negative regulation of protein homooligomerization; •negative regulation of ion transmembrane transport; •proteasome-mediated ubiquitin-dependent protein catabolic process; •positive regulation of protein homodimerization activity;
	Sources: Amigo / QuickGO
Ortólogos

Cereblon é uma proteína que ocorre em humanos codificada pelo gene CRBN.

Está envolvida no processo que causa má formação dos fetos quando a mãe utiliza talidomida.[1]

Notas e referências

Higgins JJ, Rosen DR, Loveless JM,; et al. (2000). «A gene for nonsyndromic mental retardation maps to chromosome 3p25-pter.». Neurology. 55 (3): 335–40. PMID 10932263
Ota T, Suzuki Y, Nishikawa T,; et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
Xin W, Xiaohua N, Peilin C,; et al. (2008). «Primary function analysis of human mental retardation related gene CRBN.». Mol. Biol. Rep. 35 (2): 251–6. PMID 17380424. doi:10.1007/s11033-007-9077-3
Hu RM, Han ZG, Song HD,; et al. (2000). «Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.». Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. PMC 16901. PMID 10931946. doi:10.1073/pnas.160270997
Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). «Defining the human deubiquitinating enzyme interaction landscape.». Cell. 138 (2): 389–403. PMC 2716422. PMID 19615732. doi:10.1016/j.cell.2009.04.042

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