GJC1
A proteína de junção comunicante gama-1, também conhecida como proteína junção comunicante alfa-7 e conexina 45 (Cx45) é uma proteína que nos humanos é codificada pelo gene GJC1.[1][2]
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Função
Este gene é membro da família de genes da conexina. A proteína codificada é um componente das junções comunicantes, que são compostas de conjuntos de canais intercelulares que providenciam uma rota para a difusão de materiais de baixo massa molecular de célula para célula.
Variantes de transcriptos derivados de splicing alternativo, que codificam a mesma isoforma foram descritos.[2]
Referências
- Kanter HL, Saffitz JE, Beyer EC (dezembro de 1994). «Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45». J Mol Cell Cardiol. 26 (7): 861–8. PMID 7966354. doi:10.1006/jmcc.1994.1103
- «Entrez Gene: GJA7 gap junction protein, alpha 7, 45kDa»
Leitura adicional
- Andrew L Harris and Darren Locke (2009). Connexins, A Guide. New York: Springer. 574 páginas. ISBN 978-1-934115-46-6
- Kilarski WM, Dupont E, Coppen S; et al. (1998). «Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term.». Eur. J. Cell Biol. 75 (1): 1–8. PMID 9523149. doi:10.1016/S0171-9335(98)80040-X
- Vozzi C, Dupont E, Coppen SR; et al. (1999). «Chamber-related differences in connexin expression in the human heart.». J. Mol. Cell. Cardiol. 31 (5): 991–1003. PMID 10336839. doi:10.1006/jmcc.1999.0937
- Chanson M, Scerri I, Suter S (1999). «Defective regulation of gap junctional coupling in cystic fibrosis pancreatic duct cells.». J. Clin. Invest. 103 (12): 1677–84. PMC 408381
. PMID 10377174. doi:10.1172/JCI5645 - Kausalya PJ, Reichert M, Hunziker W (2001). «Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells.». FEBS Lett. 505 (1): 92–6. PMID 11557048. doi:10.1016/S0014-5793(01)02786-7
- Laing JG, Manley-Markowski RN, Koval M; et al. (2003). «Connexin45 interacts with zonula occludens-1 in osteoblastic cells.». Cell Commun. Adhes. 8 (4-6): 209–12. PMID 12064590. doi:10.3109/15419060109080725
- Kaba RA, Coppen SR, Dupont E; et al. (2003). «Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts.». Cell Commun. Adhes. 8 (4-6): 339–43. PMID 12064615. doi:10.3109/15419060109080750
- Xiang Q, Fan SQ, Li J; et al. (2003). «[Expression of connexin43 and connexin45 in nasopharyngeal carcinoma]». Ai Zheng. 21 (6): 593–6. PMID 12452056
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Tsai MY, Lan KC, Huang KE; et al. (2004). «Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles.». Fertil. Steril. 80 (6): 1437–43. PMID 14667880. doi:10.1016/j.fertnstert.2003.05.015
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
- Valiunas V, Doronin S, Valiuniene L; et al. (2004). «Human mesenchymal stem cells make cardiac connexins and form functional gap junctions.». J. Physiol. (Lond.). 555 (Pt 3): 617–26. PMC 1664864. PMID 14766937. doi:10.1113/jphysiol.2003.058719
- Brandenberger R, Wei H, Zhang S; et al. (2005). «Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.». Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). «Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.». Genome Res. 16 (1): 55–65. PMC 1356129. PMID 16344560. doi:10.1101/gr.4039406
- Laing JG, Koval M, Steinberg TH (2007). «Association with ZO-1 correlates with plasma membrane partitioning in truncated connexin45 mutants.». J. Membr. Biol. 207 (1): 45–53. PMID 16463142. doi:10.1007/s00232-005-0803-2
- Rackauskas M, Kreuzberg MM, Pranevicius M; et al. (2007). «Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45.». Biophys. J. 92 (6): 1952–65. PMC 1861779. PMID 17189315. doi:10.1529/biophysj.106.099358
- Kotsias BA, Salim M, Peracchia LL, Peracchia C (2007). «Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes.». J. Membr. Biol. 214 (1): 1–8. PMID 17546509. doi:10.1007/s00232-006-0064-8
Ligações externas
- GJC1 - localização do gene humano no UCSC Genome Browser.
- GJC1 - detalhes do gene humano no UCSC Genome Browser.
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