Separase

Extra spindle pole bodies homolog 1 (S. cerevisiae)
Identificadores
Símbolos	ESPL1; ESP1; SEPA
IDs externos	OMIM: 604143 HomoloGene: 32151 GeneCards: ESPL1 Gene
Número EC	3.4.22.49
Ontologia do gene
Função molecular	•catalytic activity; •protein binding; •cysteine-type peptidase activity;
Componente celular	•nucleus; •centrosome; •cytosol;
Processo biológico	•mitotic sister chromatid segregation; •M phase of mitotic cell cycle; •mitotic anaphase; •meiotic spindle organization; •mitotic cell cycle; •cytokinesis; •proteolysis; •apoptotic process; •establishment of mitotic spindle localization; •homologous chromosome segregation; •positive regulation of mitotic metaphase/anaphase transition; •negative regulation of sister chromatid cohesion;
	Sources: Amigo / QuickGO
Ortólogos

Separase é uma protease de cisteína, responsável por desencadear a anáfase através da hidrólise da cohesina, que é a proteína responsável pela ligação dos cromatídios durante a metáfase. Nos seres humanos, a separase é codificada pelo gene ESPL1.[1]

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Referências

Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (fevereiro de 1996). «Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1». DNA Res. 3 (1): 17–24. PMID 8724849

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[1] Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (fevereiro de 1996). «Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1». DNA Res. 3 (1): 17–24. PMID 8724849