Xantina desidrogenase

Xantina desidrogenase
	Renderização com base em PDB 1fiq.
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	2CKJ, 2E1Q
Identificadores
Símbolos	XDH; XO; XOR
IDs externos	OMIM: 607633 MGI: 98973 HomoloGene: 324 ChEMBL: 1929 GeneCards: XDH Gene
Número EC	1.17.3.2 1.17.1.4, 1.17.3.2
Ontologia do gene
Função molecular	•xanthine dehydrogenase activity; •xanthine oxidase activity; •iron ion binding; •UDP-N-acetylmuramate dehydrogenase activity; •electron carrier activity; •protein homodimerization activity; •molybdopterin cofactor binding; •flavin adenine dinucleotide binding; •2 iron, 2 sulfur cluster binding;
Componente celular	•extracellular space; •peroxisome; •cytosol;
Processo biológico	•negative regulation of protein phosphorylation; •negative regulation of endothelial cell proliferation; •purine nucleobase metabolic process; •purine nucleotide catabolic process; •activation of cysteine-type endopeptidase activity involved in apoptotic process; •lactation; •xanthine catabolic process; •negative regulation of gene expression; •small molecule metabolic process; •negative regulation of endothelial cell differentiation; •negative regulation of protein kinase B signaling; •nucleobase-containing small molecule metabolic process; •oxidation-reduction process; •positive regulation of p38MAPK cascade; •negative regulation of vascular endothelial growth factor signaling pathway; •positive regulation of reactive oxygen species metabolic process; •negative regulation of vasculogenesis;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos

Xantina desidrogenase, também conhecimento como XDH, é uma proteina que em humanos, é codifcado pelo gene XDH.[1][2]

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Referências

«Entrez Gene: XDH xanthine dehydrogenase»
Ichida K, Amaya Y, Noda K, Minoshima S, Hosoya T, Sakai O, Shimizu N, Nishino T (1993). «Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene». Gene. 133 (2): 279–84. PMID 8224915. doi:10.1016/0378-1119(93)90652-J

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[entrez-1] «Entrez Gene: XDH xanthine dehydrogenase»

[pmid8224915-2] Ichida K, Amaya Y, Noda K, Minoshima S, Hosoya T, Sakai O, Shimizu N, Nishino T (1993). «Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene». Gene. 133 (2): 279–84. PMID 8224915. doi:10.1016/0378-1119(93)90652-J