INPP4A

INPP4A
Identifiers
Aliases	INPP4A, INPP4, TVAS1, inositol polyphosphate-4-phosphatase type I A
External IDs	OMIM: 600916 MGI: 1931123 HomoloGene: 2871 GeneCards: INPP4A
Gene location (Human)
Chr.	Chromosome 2 (human)
End	98,594,392 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	37,449,817 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; tibia; ; entorhinal cortex; ; postcentral gyrus; ; superior frontal gyrus; ; middle temporal gyrus; ; visceral pleura; ; parietal pleura; ; superficial temporal artery;
	Top expressed in
	entorhinal cortex; ; trigeminal ganglion; ; superior frontal gyrus; ; cerebellar cortex; ; Region I of hippocampus proper; ; facial motor nucleus; ; ascending aorta; ; barrel cortex; ; nucleus accumbens; ; aortic valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity; protein binding; hydrolase activity; inositol-3,4-bisphosphate 4-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; inositol-1,3,4-trisphosphate 4-phosphatase activity;
Cellular component	cytosol; cytoplasm;
Biological process	phosphatidylinositol biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; inositol phosphate metabolic process; signal transduction; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3631
	269180
	ENSG00000040933
	ENSMUSG00000026113
	Q96PE3
	Q9EPW0
NM_001134224; NM_001134225; NM_001566; NM_004027; NM_001351424;
	NM_001351425; NM_001351426; NM_001351427; NM_001351428; NM_001351429
NM_001290797; NM_001290798; NM_001290799; NM_030266; NM_172971;
	NM_001374629; NM_001374630
NP_001127696; NP_001127697; NP_001557; NP_004018; NP_001338353;
	NP_001338354; NP_001338355; NP_001338356; NP_001338357; NP_001338358
NP_001277726; NP_001277727; NP_001277728; NP_084542; NP_766559;
	NP_001361558; NP_001361559
	Wikidata
View/Edit Human	View/Edit Mouse

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.^[5]^[6]^[7]

INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000040933 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026113 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Norris FA, Auethavekiat V, Majerus PW (Aug 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J Biol Chem. 270 (27): 16128–33. doi:10.1074/jbc.270.27.16128. PMID 7608176.
↑ Norris FA, Atkins RC, Majerus PW (Oct 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J Biol Chem. 272 (38): 23859–64. doi:10.1074/jbc.272.38.23859. PMID 9295334.
1 2 "Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa".

Zhang X, Majerus PW (1998). "Phosphatidylinositol signalling reactions". Semin. Cell Dev. Biol. 9 (2): 153–60. doi:10.1006/scdb.1997.0220. PMID 9599410.
Norris FA, Atkins RC, Majerus PW (1997). "Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets". J. Biol. Chem. 272 (17): 10987–9. doi:10.1074/jbc.272.17.10987. PMID 9110986.
Munday AD, Norris FA, Caldwell KK, et al. (1999). "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3640–5. Bibcode:1999PNAS...96.3640M. doi:10.1073/pnas.96.7.3640. PMC 22347. PMID 10097090.
Joseph RE, Walker J, Norris FA (2000). "Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization". Cytogenet. Cell Genet. 87 (3–4): 276–7. doi:10.1159/000015448. PMID 10702694. S2CID 40002118.
Shearn CT, Walker J, Norris FA (2001). "Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene". Biochem. Biophys. Res. Commun. 286 (1): 119–25. doi:10.1006/bbrc.2001.5331. PMID 11485317.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ivetac I, Munday AD, Kisseleva MV, et al. (2005). "The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane". Mol. Biol. Cell. 16 (5): 2218–33. doi:10.1091/mbc.E04-09-0799. PMC 1087230. PMID 15716355.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000040933 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026113 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7608176-5] Norris FA, Auethavekiat V, Majerus PW (Aug 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J Biol Chem. 270 (27): 16128–33. doi:10.1074/jbc.270.27.16128. PMID 7608176.

[pmid9295334-6] Norris FA, Atkins RC, Majerus PW (Oct 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J Biol Chem. 272 (38): 23859–64. doi:10.1074/jbc.272.38.23859. PMID 9295334.

[entrez-7] 1 2 "Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading