Recetor de progesterona

Os recetores de progesterona, também denominados NR3C3 (recetor nuclear subfamília 3, grupo C, membro 3) são proteínas presentes no interior das células do tecido reprodutivo feminino e ativada pela hormona progesterona.[3]

PGR
Estruturas disponíveis PDB Pesquisa Human UniProt: PDBe RCSB Lista de códigos id do PDB 4OAR, 1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU, 5CC0
Identificadores
Nomes alternativos	PGR, recetores de progesterona, PR, NR3C3
IDs externos	OMIM: 607311 HomoloGene: 713 GeneCards: PGR
Targeted by Drug
dydrogesterone, Levonorgestrel, Medroxiprogesterona, noretindrona, progesterona, promegestone, tanaproget, mifepristona, acetato de ulipristal, asoprisnil, norelgestromin, nomegestrol, segesterone acetate, progesterona, onapristone[1]
Ontologia genética Função molecular • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • ATPase binding • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • steroid binding • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • enzyme binding • signaling receptor binding • lipid binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Componente celular • citoplasma • membrane • cariolinfa • mitochondrial outer membrane • mitocôndria • núcleo celular • citosol Processo biológico • GO:0009373 regulation of transcription, DNA-templated • cell-cell signaling • negative regulation of gene expression • transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • GO:0072468 transdução de sinal • steroid hormone mediated signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • ovulation from ovarian follicle • epithelial cell maturation • Mamogênese • Parácrino • lung alveolus development • regulation of epithelial cell proliferation • progesterone receptor signaling pathway • tertiary branching involved in mammary gland duct morphogenesis Sources:Amigo / QuickGO
Padrão de expressão RNA Mais dados de referência de expressão
Ortólogos Espécie Humano Rato Entrez 5241 n/a Ensembl ENSG00000082175 n/a UniProt P06401 n/a RefSeq (mRNA) NM_000926 NM_001202474 NM_001271161 NM_001271162 n/a RefSeq (proteína) NP_000917 NP_001189403 NP_001258090 NP_001258091 n/a Localização (UCSC) n/a n/a Pesquisa PubMed [2] n/a
Wikidata
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