Receptor D₅ de dopamina

O receptor D₅ de dopamina, também conhecido como D5R, é uma proteína que, em seres humanos é codificada pelo gene DRD5. Funciona como um receptor acoplado à proteína G.

DRD5
Identificadores
Nomes alternativos	DRD5
IDs externos	OMIM: 126453 HomoloGene: 20216 GeneCards: DRD5
Doenças Geneticamente Relacionadas
blefaroespasmo[1]
Targeted by Drug
A-68930, serotonina, beta-ergocriptine, bromocriptina, cabergolina, dopamina, pergolide, Rotigotina, apomorfina, lisurida, SKF-38393, (+)-butaclamol, clorpromazina, clozapina, ecopipam, Flupentixol, flufenazina, haloperidol, cetanserina, SCH-23390, espiperona, thioridazine, tavapadon, pimozida, pergolide mesylate[2]
Ontologia genética Função molecular • G protein-coupled receptor activity • dopamine neurotransmitter receptor activity • signal transducer activity • dopamine binding • dopamine neurotransmitter receptor activity, coupled via Gs • G-protein alpha-subunit binding Componente celular • integral component of membrane • membrane • membrana plasmática • integral component of plasma membrane • brush border membrane • ciliary membrane • non-motile cilium • intracellular anatomical structure • cílio Processo biológico • response to cocaine • cellular response to catecholamine stimulus • regulation of female receptivity • sensitization • adenylate cyclase-activating dopamine receptor signaling pathway • associative learning • adenylate cyclase-activating G protein-coupled receptor signaling pathway • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • transmission of nerve impulse • response to amphetamine • regulation of systemic arterial blood pressure by vasopressin • cicatrização de feridas • cellular calcium ion homeostasis • mating behavior • aprendizagem • negative regulation of NAD(P)H oxidase activity • activation of adenylate cyclase activity • reactive oxygen species metabolic process • phospholipase C-activating dopamine receptor signaling pathway • Depressão de longa duração • GO:0072468 transdução de sinal • chemical synaptic transmission • synaptic transmission, dopaminergic • G protein-coupled receptor signaling pathway • positive regulation of adenylate cyclase activity Sources:Amigo / QuickGO
Padrão de expressão RNA Mais dados de referência de expressão
Ortólogos Espécie Humano Rato Entrez 1816 n/a Ensembl ENSG00000169676 n/a UniProt P21918 n/a RefSeq (mRNA) NM_000798 n/a RefSeq (proteína) NP_000789 n/a Localização (UCSC) n/a n/a Pesquisa PubMed [3] n/a
Wikidata
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